Sorry, this question is meaningless without context. It’s too vague to make any actual sense.
I would let go of anything apart from Jen and the kids. The question here though should include the conflict that needs to be brought back into harmony.
Would I give up my life if Jen or the kids needed me to? Yes, yes I would. Would I give up my life if the conflict involved my lawn? What about a parking spot? What about whether or not the cover band should play a specific song? No. No I would not. You see the difference? What is on the table to be let go of depends on what is causing me to need to let go of something. Without that detail, whatever I say in response is meaningless.
Inside the Red Head's Head 